The pars distalis from the pituitary gland of adult male ruin lizards (Podarcis sicula campestris De Betta), captured during the five periods of the annual sexual cycle (emergence from hibernation, reproductive period, summer regression, autumnal recrudescence, Back Brace winter arrest), was studied immunohistochemically using specific antibodies a
IntroductionLeprosy is an infectious disease that remains with a high number of new cases in developing countries.Household contacts have a higher risk for the development of the disease, but the neural impairment in this group is not well elucidated yet.Here, we measured the chance of occurrence of peripheral neural impairment in asymptomatic lepr
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species.Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcMAC21) carrying a near-complete human chromosome 21.
The Research Domain Criteria (RDoC) initiative has been considered a comprehensive alternative classification framework for understanding neuropsychiatric ailments, as opposed to the longstanding, traditional DSM framework.Where the DSM categorizes neuropsychiatric disorders as each being distinct and diagnostically defined by the presence of speci
Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings.These two disciplines have separate approaches to measuring and interpreting epistasis, which is the interaction between alleles at different loci.We propose a framework for estimating and interpreting epistasis from a classical experiment th